115-year-old X-ray machine sparks back to life

Van Kleef's daughter's hand X-rayed on January 31, 1896In 1896, just a few weeks after German physicist Wilhelm Röntgen published his discovery of X-rays, H.J. Hoffmans, a high school principal, and Lambertus Theodorus van Kleef, director of a local hospital, put together an X-ray machine of their own from parts they found in Hoffmans’ high school in Maastricht, the Netherlands. They tested it on van Kleef’s daughter’s hand and it worked like a charm, a dangerously huge levels of radiation-releasing charm.

The machine ended up in storage at the Maastricht University Medical Center where it was promptly forgotten until it was dug up last year to use as a visual aid in a documentary on the history of medicine in the area. Curiosity piqued, MUMC medical physicist Gerrit Kemerink decided to run the old machine through its paces and see what it could do.

“To my knowledge, nobody had ever done systematic measurements on this equipment, since by the time one had the tools, these systems had been replaced by more sophisticated ones,” said Dr Kemerink.

Kemerink’s team thought it best to use a cadaver hand to experiment on this time around rather than somebody’s lovely daughter since the radiation emitted by this very early machine was likely to be dangerously high. (People didn’t realize radiation could be harmful until a year after Röntgen’s discovery.) The researchers used the original equipment — an iron cylinder wrapped in wire and a glass bulb called a Crookes tube with electrodes at each end — powered by a modern car battery.

Cadaver hand X-rayed with 1896 machine (left) and modern (right)They used both a modern hospital radiation detector and the glass photographic plate Hoffman and van Kleef originally used, and found that using the modern detector the machine took a fairly clear picture but there was some blurring from the wide scatter of the X-rays and the cadaver hand got hit with a dose of radiation dose 10 times higher than it would have received from a modern system. Using the far less sensitive period photographic plate, the team found that the machine gave the skin a dose of radiation 1,500 times higher than it would receive from a modern machine.

The researchers were of course protected by a lead shield whenever the machine is on, but the experiments didn’t produce enough radiation to harm them. It sure did look and sound fantastic, though.

“Our experience with this machine, which had a buzzing interruptor, crackling lightning within a spark gap, and a greenish light flashing in a tube, which spread the smell of ozone and which revealed internal structures in the human body was, even today, little less than magical,” they wrote.

It’s very 1931 Frankenstein, only in color. You can see and hear it in action in this video from Wired:

World’s largest Megalodon jaw for sale

I try, as a matter of blogger policy, to find a good picture with every story because I’m always disappointed when I read about something that sounds awesome but there’s no picture of it. Today, however, the picture came first.

Largest Megalodon jaw fossil

I KNOW, RIGHT?! That immense coolness is the largest Megalodon jaw ever assembled. It’s 11 feet wide and 9 feet tall, and it’s for sale.

It was put together by the late Vito Bertucci, a jeweler and amateur scuba diver who became known as “Megalodon Man” for his dedication to hunting fossils of the giant prehistoric shark that dominated the oceans between 2.5 million and 1.5 million years ago. He spent years collecting fossils of Megalodon teeth, studying their proportions and assembling complete toothy Megalodon jaws for venerable institutions like the American Museum of Natural History in New York and the Baltimore Aquarium.

This one is the biggest one he ever made. It took him over 16 years diving the mid-Atlantic coastal plains to collect enough of the largest teeth — they’re much rarer than the smaller ones — to compose this marvel.

Detail of Megalodon teethPositioned with scrupulous scientific accuracy in a pair of jaws modeled in resin and scaled up from a Great White jaw set, the teeth are accurately arrayed in four rows; each row at a different angle for maximum efficiency in rending the flesh of the great fish’s victims. The jaws contain four teeth that each measure over 7 inches along the diagonal, although this is not immediately obvious because part of the roots are embedded in the jaw.

Megalodon’s skeletal structure was made of cartilage which very rarely fossilizes, so it wasn’t like Bertucci could just find a jawbone, collect an appropriate number and size of teeth then slot them in where they fit. Complete sets of teeth have been found, but none of this dramatic scale. He had to do a lot of research and examination of the teeth to figure out how they would have fit together. It took him a year and a half to piece it together once he had collected all the fossils.

It would be his last masterpiece. He died in October 2004, while diving for fossils in the Ogeechee river south of Savannah, Georgia. His brother, Joey Bertucci, is selling the jaw. The estimated sale price is $700,000.

Confirmed: Y. pestis bacteria caused the Black Death

Yersinia pestis in the lymph of a plague patientMost microbiologists, epidemiologists and historians agree that the Black Death, the plague that devastated Europe between 1347 and 1353 killing at least a third of the population, was caused by the bacteria Yersinia pestis. Endemic to rodent fleas in China, Y. pestis is thought to have made its way to Europe over the Silk Road and/or sea trade routes.

There are, however, people who disagree that the Black Death was actually bubonic and pneumonic plague caused by Y. pestis. The primary alternate theory was that it wasn’t a bacterial disease spread by parasites on vermin, but rather an infectious Ebola-like viral hemorrhagic fever that was spread from person to person. The evidence for this was primarily historical — the effectiveness of quarantine, for instance, in stopping the spread of disease.

Now a new study (pdf) from an international team of researchers appears to have conclusively demonstrated that Y. pestis was indeed the cause of the Black Death and all subsequent outbreaks of the plague in Europe. Researchers tested the DNA in tooth pulp recovered from the plague victims buried in plague pits in Hereford, England, Saint-Laurent-de-la-Cabrerisse, France, Bergen op Zoom, the Netherlands, Augsburg, Germany, and Parma, Italy, among others.

They were able to identify the DNA and protein signatures for Y. pestis, and while they were at it, they also discovered two previously unknown clades of the bacterium, both of them ancestors of the Orientalis (the one that devastated India and China in the late 19th century) and Medievalis (the Black Death one) biovars. This suggests that the plague didn’t just come to Europe once over one route. There were at least two distinct pathways Y. pestis took to get to Europe.

Several historical epidemic waves of plague have been attributed to Yersinia pestis, the etiologic agent of modern plague. The most famous of these was the second pandemic which was active in Europe from AD 1347 until 1750, and began with the ‘Black Death’. The most informative method to establish the etiological nature of these ancient infections should be the analysis of ancient DNA, but the results of this method have been controversial. Here, by combining ancient DNA analyses and protein-specific detection, we demonstrate unambiguously that Y. pestis caused the Black Death. Furthermore, we show that at least two variants of Y. pestis spread over Europe during the second pandemic. The analysis of up to 20 diagnostic markers reveals that the two variants evolved near the time that phylogenetic branches 1 and 2 separated and may no longer exist. Our results thus resolve a long-standing debate about the etiology of the Black Death and provide key information about the evolution of the plague bacillus and the spread of the disease during the Middle Ages.

If you’d like to read more about the arguments for and against Y. pestis causation, I highly recommend this excellent series of articles by epidemiologist and Aetiology blogger Tara Smith. They’re from three years ago so they don’t address the recent study, of course, but they’re eminently readable and thoroughly address the issues on all sides.

WWII Red Cross volunteer gets letter from 1944

Letter to R.T. Fletcher

On February 16, 2001, Gary McMaster, curator of the Camp Roberts Historical Museum on what is now a training base for the Califor­nia Army National Guard, received a letter postmarked August 9, 1944. The hand-written envelope was addressed to Miss R.T. Fletcher, at the base’s Red Cross hospital. Since the hospital had been torn down decades earlier, the mail carrier figured the historical museum would be a reasonable substitute.

Naturally McMaster was intrigued by this piece of World War II history dropped in his mailbox as if it had been sent days ago. He decided to try to find the addressee, but out of concern for their privacy, without reading the letter. USPS had no information. It could have come from the dead letter depot in Atlanta, but according to Joseph Brecken­ridge, a postal service spokesman in Atlanta, it’s more likely someone just found the letter in an attic somewhere and decided to pop it in the mail. The return address was obscured by a tear in the envelope, but the postmark marked its departure point as Montgomery, Alabama.

He decided to tell the Montgomery Advertiser about the letter, hoping against hope that the sender, the recipient or relatives who could perhaps recognize the letter might still live in the area and would see the article. The newspaper ran the story and it caused a little sensation. The AP picked it up, and soon McMaster was getting inquiries about the letter from press around the world.

One of the stories was seen by R. T. Fletcher’s daughter. She recognized her mother’s maiden name and the handwriting on the envelope as that of her uncle, her mother’s brother, who was a soldier stationed at Maxwell Field in Mont­gomery in August of 1944. She faxed McMaster copies of other letters he had written her mother during the war, and the handwriting did indeed match. Although sadly her uncle had passed away years ago, Miss Fletcher is 90 years old and still going strong.

There was also another, even more awesome, clue that this was the right person. Miss Fletcher had told her daughter stories about the time she performed on stage with comedian Red Skelton at Camp Roberts.

McMaster said Camp Rob­erts was one of the largest ar­tillery training centers in World War II.

“We had people from all over the country at Camp Roberts,” he said, including Robert Mitchum, William Holden and Red Skelton.

Fletcher had told her fami­ly that while she served at Camp Roberts, she was in a play that featured Skelton, a popular comedian. McMas­ter was able to find a pro­gram from that show at the museum.

Lo and behold, her name was on the program as a bit player in this Red Skelton scrapbook.”

Turns out that Fletcher was a Red Cross volunteer, and she was coordinating en­tertainment for the soldiers and patients at the hospital at Camp Roberts. Many of them were recuperating from combat injuries, McMaster said.

McMaster had just recently mounted an exhibit at the museum about Red Skelton’s time on the base, which is why he had the scrapbook handy.

With the Skelton evidence and the handwriting match, Gary McMaster was satisfied that he had found the addressee. The letter is currently winding its way to Miss Fletcher’s daughter via registered mail. She will then deliver it to her mother in person, 66 years after it was first sent.

Smithsonian conserves Jefferson Bible

Jefferson Bible title page, binding removedIn 1820, when Thomas Jefferson was 77, he scared himself up a Bible. He didn’t write one. He created one by literally cutting and pasting passages from six books of the New Testament in four languages, English, French, Greek and Latin. It wasn’t something he intended to publish or even publicize. Jefferson conceived it as a personal philosophical exploration of deism and Jesus’ ethical system. He called it “The Life and Morals of Jesus of Nazareth” and he intentionally omitted any references to the divinity of Christ, miracles or any supernatural intervention.

Jefferson Bible coverHe used a razor to clip out passages, then glued them in four columns (one for each language) to both sides of a piece of paper. The final tally is twelve different kinds of paper and seven different inks over 86 pages which were then professionally bound in gold-tooled Morocco leather with a hand-sewn binding. Jefferson kept it his whole life, never gave it away or sold it, and despite his many debts, his heirs kept it in the family for decades.

The Smithsonian’s librarian finally purchased the Bible from Jefferson’s great-granddaughter Carolina Randolph in 1895. Nine years later the Government Printing Office made lithographic reproductions of the Bible for distribution to new members of Congress. It was a one-time run, though, and no further copies were made.

Jefferson Bible pagesNow, almost 200 years after Jefferson first created his Bible scrapbook, it’s in dire need of restoration. The pages are stiff and inflexible from the glue and clippings, with 90% of them damaged in some way. The binding remains tight, which isn’t a good thing when the pages are so brittle.

Conservators have removed the pages from the binding. Once they’re cleaned and stabilized, the pages will be returned to the original binding so that the book can go on display at a proper 90 degree viewing angle. The Smithsonian estimates the restoration will cost $225,000 and are raising money to cover the costs from public and private sources. If you’d like to donate to help preserve the Jefferson Bible, please click here.

The National Museum of American History blog will be posting a series of entries on the conservation, starting with this one. Once the Bible is fully restored, it will be digitally scanned and uploaded for public viewing. There will also be a companion website with more information about the Bible, the conservation process, and Jefferson’s annotations and edits.