Crick writes his 12-year-old son about DNA model

On February 28th, 1953, Francis Crick and James Watson figured out that DNA had a double-helix structure by creating a model out of bits of stuff in the lab and comparing it to X-ray diffraction data collected by X-ray crystallographer Rosalind Franklin and molecular biologist Maurice Wilkins. It was a discovery to write home about, and on March 19th, Crick did just that, sending a letter to his 12-year-old son Michael (who was not actually home at the time but rather in boarding school) describing their model, the double-helix sugar-phosphate backbone zipped together with basepairs of guanine and cytosine, adenine and thymine.

This letter, written more than a month before Watson and Crick published their first paper in the April 25th, 1953, issue of the journal Nature, contains the first written description of DNA as a “code” that is replicated. In addition to marking a watershed moment in the history of science, it’s a model of clarity and science writing for a popular audience that I think should be included in every school science textbook published. It’s also really sweet in a my-dad-is-a-serious-scientist sort of way.

My Dear Michael,

Jim Watson and I have probably made a most important discovery. We have built a model for the structure of des-oxy-ribose-nucleic-acid (read it carefully) called D.N.A. for short. You may remember that the genes of the chromosomes — which carry the hereditary factors — are made up of protein and D.N.A.

Our structure is very beautiful. D.N.A. can be thought of roughly as a very long chain with flat bits sticking out. The flat bits are called the “bases”. […]

Now we have two of these chains winding round each other — each one is a helix — and the chain, made up of sugar and phosphorus, is on the outside, and the bases are all on the inside. […]

Now the exciting thing is that while these are 4 different bases, we find we can only put certain pairs of them together. The bases have names. They are Adenine, Guanine, Thymine & Cytosine. I will call them A, G, T and C. Now we find that the pairs we can make — which have one base from one chain joined to one base from another — are only A with T and G with C.

Now on one chain, as far as we can see, one can have the bases in any order, but if their order is fixed, then the order on the other chain is also fixed. […]

It is like a code. If you are given one set of letters you can write down the others.

Now we believe that the D.N.A. is a code. That is, the order of the bases (the letters) makes one gene different from another gene (just as one page of print is different from another). You can now see how Nature makes copies of the genes. Because if the two chains unwind into two separate chains, and if each chain then makes another chain come together on it, then because A always goes with T, and G with C, we shall two copies where we had one before. […]

In other words, we think we have found the basic copying mechanism by which life comes from life. The beauty of our model is that the shape of it is such that only these pairs can go together, though they could pair up in other ways if they were floating about freely. You can understand that we are very excited. We have to have a letter off to Nature in a day or so. Read this carefully so that you understand it. When you come home we will show you the model.

Lots of love,
Daddy

I’ve snipped out the hand-drawn illustrations, but you can read a transcript of the full letter with the diagrams included here. Crick’s handwriting is very legible so you can easily read the full letter with diagrams in the pictures below.


Michael did what his father told him to do and read the letter carefully over and over again. He was sick with the flu and confined to quarters, so he had plenty of time on his own to reread it and memorize “des-oxy-ribose-nucleic-acid” and grasp how the code could be copied.

The little boy is 72 now and kept the letter for 60 years. He put it up for auction this year, the 60th anniversary of its writing, because it was idling away in storage along with Francis Crick’s Nobel Prize, which Crick, James Watson and Maurice Wilkins (Rosalind Franklin had died in 1958 and prizes are not awarded posthumously), received in 1962 after the immense significance of their discovery became clear. Michael and his family decided it was time to let go of these precious milestones in the history of science. The proceeds would be split, with 20% from the sale of the medal going to the Francis Crick Institute in London and 50% from the sale of the letter going to the Salk Institute in La Jolla which employed Crick for 27 years after his mandatory retirement from the Medical Research Council in Cambridge, England, the laboratory where Watson and Crick made the double-helix model.

On April 10th, 2013, the letter sold at a Christie’s auction in New York for $5.3 million, $6,059,750 including buyer’s premium. This is a world record price for a letter sold at public auction. The buyer has chosen to remain anonymous, surprise, surprise. I hope he’s willing to lend it to institutions for exhibition.

Crick’s Nobel prize medal and diploma were sold by Heritage Auctions on April 11th. They were bought for $2,270,500 by Jack Wang, CEO of a Shanghai-based biomedical firm who plans to display them to encourage the company’s scientists to reach great research heights.

The original model of the double-helix made by Crick and Watson was dismantled, but in 1973 it was recreated using many of the original metal plates representing the bases. The reconstructed model is now part of the permanent collection of London’s Science Museum.

Gettysburg Civil War wax museum for sale

The American Civil War Wax Museum in Gettysburg, Pennsylvania, is for sale. The 12,450 square-foot building, all of its contents, plus the adjacent Veteran’s Park with its native plants and shade trees can be yours for the bargain price of $1,695,000.

Founded in 1962 by Polish immigrant C.M. Uberman, the museum today boasts more than 300 life-size wax figures arranged in 35 scenes depicting important events in the Civil War. It’s the only museum in Gettysburg that focuses on the entirety of the war, although of course it also gives due prominence to the Battle of Gettysburg and Lincoln’s Gettysburg Address. There’s a Battle Room in which the figures combine with digital enhancements and sound to recreate the feeling of being at the Battle of Gettysburg, followed by an animated figure of Abraham Lincoln delivering the address.

Living history displays with Civil War reenactors take place outside from April through November. The museum hosts book signings, live performances of Civil War music, lectures from experts in everything from Civil War artillery to Victorian hair jewelry to newspaper printing and all kinds of other neat events.

More than eight million visitors have enjoyed the museum since its opening, and this year being the 150th anniversary of the Battle of Gettysburg (which took place July 1–3, 1863), there’s sure to be a boost in visitor numbers. So why are they selling, you ask? It’s a family run business and the owners are ready to retire but the children aren’t interested in taking over. Public sale is the result, and there won’t be any conditions so the new owners can either keep the museum open or just buy it for the property. The good news is there are several interested buyers and all of them have told the owners they would keep the museum running.

Meanwhile, there are all kinds of 150th anniversary events scheduled through the end of the year. General Manager Tammy Myers says they expect the 2013 schedule to remain unchanged, sale or no sale.

I haven’t been to this museum personally, but from the pictures I’d say the wax figures and dioramas are on the rudimentary side. There’s a lot of room, I think, for new owners to bring in a fresh perspective and spruce up the displays. Wax figures can be amazingly lifelike nowadays and when it comes to backdrops and settings, digital elements could really boost the sense of realism. Given the relatively low cost of the property and the reliable stream of income from visitors and gift shop purchases, a Civil War buff with deep pockets could get a great return on investment by renovating the exhibits.

Newly discovered miniature of Elizabeth I as Paris

In July of 2012, a previously unknown miniature depicting Queen Elizabeth I as the central figure in a reimagining of the Judgment of Paris sold at Christie’s for $453,833, five times its pre-sale estimate. It was purchased by an art dealer who arranged for its sale to the National Portrait Gallery. Although the NPG has nine portraits of Queen Elizabeth, this is the first one that has an allegorical theme which makes the little piece a hugely significant addition to the gallery’s permanent collection.

The postcard-sized (4.5 × 6.25 inches) chalk, gouache and gold on vellum painting was found during a house clearance in south-east England. It’s very rare to find a work of such high quality that has never been published before and allegorical images of Queen Elizabeth I are rare enough as it is. The style of the clothing dates it to around 1590.

The piece is unsigned, but various features and its high quality mark it as the work of Isaac Oliver, a French-born Huguenot miniaturist who was the greatest student of court painter Nicholas Hilliard, known for his miniature portraits of royalty. It’s a re-working of Elizabeth I and the Three Goddesses, a full-sized painting in the Royal Collection at Hampton Court from 1569 originally attributed to Hans Eworth but now thought to have been painted by Joris Hoefnagel.

In both paintings, Elizabeth holds the Golden Apple of Discord while the three goddesses — Juno, Minerva and Venus — vying for it back away. Elizabeth is both Paris, the prince of Troy who is supposed to assign the apple to the most beautiful of the three, and the ultimate recipient of it. She spurns the discord the apple is intended to cause and instead just keeps it, making her the most beautiful of them all and the bringer of peace. In the Hampton Court painting, Juno appears to be beckoning at her, a suggestion that the Queen follow her into marriage, perhaps, but by the time of the miniature 20 years later, Juno’s extended arm appears to be blocking Venus instead. Elizabeth was no longer susceptible, the allegory suggests, to the blandishments of love and marriage.

The 1569 painting was the first allegorical portrait she had made and the Judgment of Paris was a particularly pointed theme for Elizabeth. Her mother, Anne Boleyn, had been regaled with pageants on that same subject during her coronation procession which took place in May of 1533, when she was already five months pregnant with the future Queen Elizabeth.

The marriage of Henry VIII and Catherine of Aragon had been declared null and void by Archbishop of Canterbury Thomas Cranmer on May 23rd; Cranmer declared Henry and Anne’s wedding (there was a secret ceremony in December followed by a public one in January after she got pregnant) valid on May 28th. The next day coronation ceremonies began. After two days of barge trips and ceremonial processions, Anne Boleyn was crowned Queen Consort of England on June 1st, 1533.

There are two main accounts of the coronation, one by Edward Hall who was one of the organizers of the festivities, published in a 1548 two-volume history of Tudor kings known as Hall’s Chronicle, and the other a pamphlet by Wynkin de Worde printed in 1533 entitled The Noble Tryumphaunt Coronacyon of Quene Anne, Wyfe unto the Noble Kynge Henry the VIII.

Most of these pageants were mythological allegories involving Greco-Roman deities and heavy-handed symbolism about Anne’s great beauty, chastity (really), fertility and general worthiness to be Queen, a matter by no means universally accepted at this time since Catherine’s spurning and the break with Rome were enormously controversial fresh wounds. Here’s Hall’s description of the Judgment of Paris pageant:

And so roade to the lytle Conduyte, where was a riche pageaunt full of melodye and song, in which pageaunt were Pallas, Iuno, and Venus, and before them stode Mercury, whiche in the name of the three goddesses gave unto her a balle of gold, devided into three, signifying three gifts which these three goddesses gave to her, that is to say, wysedome, ryches, and felicitie.

Here’s Wynkin de Worde’s description of same:

And so her grace passed a lytell further and at the lesser Condyt was a costly and a ryche pagent whereas was goodly armonye of musyke and other mynstrels with syngyng. And within that pagent was fyve costly seates wherin was set these fyve personages that is to wete Juno, Pallas, Mercury and Venus and Parys hauyng a ball of golde presentyng it to her grace with certayne verses of great honour and chyldren syngyng a balade to her grace and prayse to all her ladyes.

Those verses of great honour were written by Nicholas Udall and John Leland who had been enlisted to create English and Latin poems to accompany the pageants and tableaux vivants along the route of the coronation procession from the Tower of London to Westminster Palace on May 30th, 1533.

Udall and Leland’s verses about the Judgment of Paris tableau:

The proud goddesses assaulted great Jove with their immoderate entreaties, asking him for the little golden prize bestowed on consummate beauty. Therefore at the behest of his Dictys-born father [Jupiter], the child of African Atlas [Mercury] flew through the clouds as a companion to the goddesses, and gave the apple to comely Paris as he was pasturing his flocks in the groves of Phrygia’s Mt. Ida, and now the Dardanian [Trojan] shepherd, shaking off his easy sleep, grasped it in his hand, so he might quickly employ his keen judgment to bestow it on a goddess of especial beauty for her enjoyment. Meanwhile the consort of supreme Jove, impatient of delay, demanded this prize of conquering beauty, promising Paris proud realms. Pallas offered her arts, if the prize for comeliness were granted her. Venus, promising him the beds he desired, staked her claim on the little reward of the golden apple. Straightway Paris sweetly smiled, and, casting around his delightful eyes and pointing at Anne, said, “Behold, you may see a woman supreme in all respects, and deserving to carry off even three hundred apples thanks to the goodliness of her virtues. No small gift must be given to Anne. The scepter awaits her, as does the crown, a fitting reward for her virtues. He who bid you come here in search of prizes of beauty, goddesses, set a trap for you, and when he sent you here the Thunderer wanted you to be suffused with no small amount of blushing. You take the apple, Venus, and now all you goddesses may go back to high heaven.”

Many men have told me that Dardanian Paris was an elegant witness to beauties and to all comeliness when, a proud shepherd, he was leading his snow-white flocks over lofty Ida, and with his thrice-fair hand gave the golden apple to Venus, to the indignation of Minerva and Jove’s sister, until comely Anne came along. Thinking this over frequently, I could not see the point of these amazing mysteries until you, divine Venus, came down from heaven on a quick course to us oceanic English and cheerfully gave the golden apple to a woman fairer than yourself, Anne, whose pretty head will soon be encircled by the beauty of a crown gleaming with jewels.

And whose pretty little neck would soon after that be separated from her pretty head.

Elizabeth’s embrace of this particular allegory was a recognizable and highly pointed tribute to her mother. Instead of avoiding the tendentious matter of the legitimacy of Anne’s marriage and thus her own legitimacy as her father’s heir, she chose to associate herself with her mother’s reign as queen of England and reclaim her place as the daughter of royalty on both sides. In the Hampton Court painting, Elizabeth is wearing St. Edward’s Crown, the same imperial crown that Anne was crowned with in 1533.

She had Elizabeth I and the Three Goddesses hung in Whitehall Palace near the 1537 Hans Holbein mural of the Tudor dynasty Henry had commissioned when Elizabeth’s half-brother Edward was born. That version of the Tudor dynasty featured King Henry VII back left, King Henry VIII front left, his mother Elizabeth of York back right and Jane Seymour, Henry’s his third wife and mother of his only son, front right. Nobody else made the cut. In this mural her father had tried to scrub Anne and Elizabeth out of the Tudor line; Elizabeth put them both back through the Judgment allegory.

Elizabeth was queen regnant, not queen consort, so as much as the allegory recognized Elizabeth’s matrilineal royalty, it also made a stronger statement about Elizabeth’s status as undisputed ruler. Unlike her mother, she doesn’t receive the apple from Paris or even Venus; she takes the man out of the equation altogether and appoints herself the winner. The three goddesses don’t just accept her as one of their own as they did Anne Boleyn; they acknowledge her as dominant. Juno even loses a shoe in her haste to step back from Elizabeth Regina. The apple she holds is the sovereign’s orb, although in the miniature it doesn’t have the cross and straps of the official orb, it is still a gigantic golden orb indicative of her majesty.

Both the miniature and the Hampton Court painting will go on display at the NPG’s new exhibition Elizabeth I & Her People which will run from October 10th, 2013, through January 5th, 2014. The exhibit will include many portraits of Elizabeth, her court, explorers, ambassadors along with merchants, financiers, lawyers, artists and others who were part of the diverse social classes on the rise in Elizabethan England. Believe it or not, the gallery had already arranged the loan of the larger painting before the miniature appeared on the market. The timing of the find could not have been more fortuitous for the National Portrait Gallery.

Tesla Wardenclyffe laboratory bought for museum

Last year’s hugely successful Indiegogo campaign to raise $850,000 for the nonprofit Tesla Science Center to build a museum dedicated to the genius inventor Nikola Tesla at his Wardenclyffe laboratory in Shoreham, New York, has borne fruit. The 15.69-acre laboratory site and all its buildings are no longer the property of Belgian multinational Agfa. As of May 2nd, the last laboratory of Nikola Tesla still standing anywhere in the world officially belongs to the Tesla Science Center at Wardenclyffe (TSCW). Agfa, who put the property up for sale for $1.6 million and was reportedly entertaining an offer from real estate developers to demolish the historic structures and build condos on the site, now says via its North American general counsel Christopher Santomassimo that it “is proud to be associated, albeit in a small way, with this historic event.”

It took two decades of unrelenting effort from the Tesla Science Center at Wardenclyffe to pay Agfa off so this historic event could take place. New York State had offered matching funds to make the purchase, so the TSCW needed to come up with $850,000 to meet Agfa’s asking price. When they found out that an interested developer was looming on the horizon last summer, they kicked off a public fundraising campaign. Matthew Inman of the massively popular website The Oatmeal, an avowed Tesla fan, got involved. He started an Indiegogo fundraiser entitled “Operation Let’s Build a Goddamn Tesla Museum,” offered extensive donation incentives and promoted the campaign heavily on his high-traffic site. Within a week, the campaign raised a million dollars. The final tally was $1,370,000.

It’s been almost nine months since then. Finally owning the property is a major milestone for the Tesla Science Center, but they don’t have time to rest on their laurels because the buildings are dilapidated, the grounds a wilderness and it’s going to take a great deal more money and time to convert this former Superfund hazardous waste site into a museum.

The TSCW has ambitious plans. They want to take advantage of the complex to create a museum about Tesla and his work, a hands-on science learning center where workshops will be held for inventors, a replica of the 187-foot power tower which was destroyed by the government in 1917 and, perhaps the coolest idea of them all, a physics-themed playground. The estimated cost to make this vision a reality is $10,000,000. The extra $520,000 raised on Indiegogo on top of the $850,000 used for the purchase gives them a little breathing room to get cleanup started, but isn’t even a dent on the total costs for the creation of the museum.

They’re not wasting any time doing what they can do, though. They’s already begun to board up the buildings to keep destructive human and animal elements out. Next on the agenda is a thorough assessment of their condition. Not all buildings can be saved, which is fine because many of them were built after Tesla sold the lab in 1915. The ones that are structurally viable will be restored and integrated into the design of the museum. The rest will be demolished.

Clean-up and construction will take an estimated five years. The TSCW plans to further fundraising to raise the $10 million. They expect corporate donors to provide the bulk of the amount, although considering that the Veronica Mars movie raised a record-breaking $5 million on Kickstarter, who knows what might be accomplished with crowdfunding these days?

Here’s video of the press conference announcing the purchase held at the New Yorker Hotel in Manhattan, where Tesla spent the last ten years of his life in Suite 3327 feeding pigeons and meeting the occasional dignitary. He died there on January 7th, 1943.

The video includes talks from the “Angel Investors,” three people who donated key large amounts that helped the campaign meet its goals. The first to speak around the 15 minute mark is Joe Sikorski, a filmmaker who shot a Tesla documentary Fragments from Olympus and is working on a second documentary called Tower to the People about the inventor’s Wardenclyffe laboratory. The Sikorskis donated $33,000, all their seed money for the film, to the fundraising campaign. That was the donation that took them over the top to the $850,000 necessary to secure matching funds.

Next around the 20 minute mark is a great talk from Greg and Meredith Tally of the Best Western Denver Southwest who are awesomely turning the hotel into a paleontologically correct dinosaur resort. Big fans of Tesla and science boosters in general, they donated $35,000 to the Indiegogo campaign, which earned them a custom comic by Matthew Inman dedicated to the greatness that is the Dino hotel. They have a great bit describing Tesla’s laboratory in Colorado.

The last Angel is venture capitalist Dusan Stojanovic who gives an animated, passionate speech at the 26 minute mark encouraging wealthy companies to “put some cash into the future.” He is actually distantly related to Tesla. He shows his family tree and the piles of Tesla cousins that include his little branch. He will plans to put that kickass family tree online as part of the museum project.

He’s not the only Tesla relative to speak at the press conference. William Turbo, Tesla’s great grandnephew (his grandmother was Nikola Tesla’s sister) who knew him personally speaks around the 44 minute mark. He’s the Executive Secretary of the Tesla Memorial Society and notes there’s been a marked spike in interest in the inventor who was famous until his death but then faded into relative obscurity.

Revolutionary War frontier fort site found in Georgia

Archaeologists from the LAMAR Institute (the research organization that also played a pivotal role in the discovery of the Civil War prison Camp Lawton) have found the location of a small frontier fort which was the site of a significant Revolutionary War skirmish in Wilkes County, east central Georgia.

This was an incredible long shot. There are no contemporary maps pinpointing its location, only a few vague landmark descriptions in the primary sources. Researchers and surveyors identified about a dozen potential sites inside a search area of 2,700 wooded acres. With a limit budget funded by grants from the National Park Service American Battlefield Protection Program, Kettle Creek Battlefield Association, and the LAMAR Institute, a team of six people had one month to scour this vast area with metal detectors looking for remains of the fort and battlefield.

After a month of searching turned up more than a dozen 18th century settlements but no fort and no battlefield, they hit paydirt in the form of musket balls literally on the last hour of the last day of the project. With no money left in the budget to keep going, the team all volunteered to return for a few more days to find more evidence that they’d discovered Carr’s Fort. They unearthed a dozen fired musket balls, musket parts and hundreds of iron and brass artifacts from decorative scrollwork to horseshoes, buttons, door hinges and old frying pans.

This was not the engineered military fortification you think of when you think of forts. Robert Carr was a cattle farmer and captain in the Georgia Patriot militia. Part of his duties as a militia captain was to create a safe shelter for his men and their families should they find themselves under attack by Loyalists or hostile Native Americans. He built a stockade around his home and several outbuildings making a space the size of a tennis court where about 300 people could find some protection from enemy incursions. That’s Carr’s Fort.

There were more than 30 militia forts along the Wilkes County frontier during the Revolutionary War. This is the first one to have been found archaeologically. Modest though it may have been, this fort and the other frontier forts like it were strategic keys to holding Georgia.

Savannah had been captured by British troops under Lieutenant Colonel Archibald Campbell on December 29, 1778, an important victory for the British who were trying to reclaim the prodigal South in the wake of their failures in the North. In January, Campbell and his men were sent north to Augusta to recruit Loyalist militia. He met with limited success — many of the so-called Loyalists he signed never actually got around to forming militia companies — but Colonel John Boyd, who Campbell had sent on a recruiting mission to North and South Carolina, was able to recruit almost 800 Loyalists in his journey to and back from the Carolinas.

In response to the loss of Savannah, the Continental Army, chronically short of funds and manpower, had managed to scrounge up about 1,500 Patriot militiamen camped on both the Georgia and South Carolina banks of the Savannah River near Augusta. Under the command of Colonel Andrew Pickens, the militias went on the offensive, attacking Campbells’ camp just outside Augusta. They arrived to find it empty, however. The British were on an extended patrol. Pickens sent most of his men after them but directed a group of 250 men to Carr’s Fort just in case the Loyalists were planning on trying any funny business there.

Pickens’ instincts (or intelligence) was spot-on. A troop of 80 Loyalists led by Campbell had occupied Carr’s Fort, but since the Georgia and South Carolina militia was hot on their heals, they had been forced to leave their horses and baggage train outside of the stockade walls. On February 10, 1779, the Patriot militia besieged the fort and a very short, very intense battle ensued. They exchanged fire for several hours leaving more than a dozen dead and wounded on each side.

It only ended because Pickens found out that Boyd’s 800 Loyalists were headed for Georgia from South Carolina, so he ordered the siege lifted and went to intercept Boyd. The Patriots took the Loyalist horses and baggage with them. Stranded without transportation or supplies, Campbell’s detachment left Carr’s Fort and marched back to Savannah to rejoin the main garrison. Pickens intercepted Boyd four days later on Valentine’s Day near Kettle Creek. The Patriots won. Boyd was mortally wounded and most of his troops were captured, wounded, killed or fled. About 250 of Boyd’s militia would eventually join up with Campbell’s forces.

Captain Carr, who may or may not have been present when the fort was besieged (the sources on the battle don’t mention him at all), was killed a few weeks later at his home by Loyalist Creek Indians who burned down the fort. His his wife and children were able to escape.

The artifacts recovered from the Carr’s Fort site are being cleaned. When that’s done, they will be given to University of Georgia. Daniel Elliott, President of the LAMAR Institute, says researchers are still looking for any remains of the stockade wall that may have survived the conflagration.