Archive for January 7th, 2013

2000-year-old shipwreck pills were an eyewash

Monday, January 7th, 2013

A shipwreck from 140 – 130 B.C. first discovered in 1974 off the coast of Tuscany near the Etruscan town of Populonia was found upon later excavation to contain a vast collection of trade goods from around the Mediterranean. Packed in the small ship (it’s at most 60 feet long and 10 feet wide) were Syrian glass bowls found still in stacks, pottery from Pergamon, wine amphorae from Rhodes, lamps from Ephesus, coins, lead vessels and other consumer goods. The most intriguing find, however, was a large cache of medical equipment. Tin cylinders called pyxides, 136 boxwood vials, a stone mortar, an iron probe and a bronze cupping vessel of a type used for bloodletting or for applying hot air to aching body parts, were discovered next to an iron lock that once belonged to a wooden box long since rotten away.

Inside one tin pyxis was a rare archaeological treasure: five grey disc-shaped tablets stacked on top of each other like Mentos. Despite having spent 2120 or so years wrapped in dense marine flora on the seabed of the Baratti Gulf, the pyxis had remained water tight and the tablets were still intact. In 2010, scientists published the first DNA analysis on the tablets. They found evidence of a wide variety of plant matter — carrot, radish, parsley, celery, wild onion, cabbage, alfalfa, yarrow, hibiscus — in the pills, plants known from ancient sources to have been used for medicinal purposes. The still weren’t sure exactly what ailments the tablets would have been prescribed to cure, nor how they would have been taken by patients.

Now a team of Italian researchers has thinks they’ve found the answer: they were probably used as an eyewash. Archaeologists from the Archaeological Superintendence of Tuscany, chemists from the University of Pisa and evolutionary biologists from the University of Florence examined the components of samples taken from a broken tablet with a scanning electron microscope, X-ray spectroscopy, infrared spectroscopy, X-ray powder diffraction and gas chromatography/mass spectrometry. They found that the main inorganic element was zinc. Zinc compounds like hydrozincite (zinc hydroxycarbonate) and smithsonite (zin carbonate) make up 75% of the tablet. Silicon and iron are second and third with 9% and 5% respectively.

Organic components identified include starches that show evidence of having been cooked, animal lipids, vegetal lipids, beeswax, pine resin, 53 kinds of pollen and trace amounts of vegetal charcoal. Most of the pollen, 40%, was olive pollen. The runner-up with 13% was wheat. There were also some linen fibers, more of them on the outer part of the sample than the inner which could be the remnants of fabric used to wrap the pills. Any fabric that might have been cradling the tablets has decayed, but you can still see a texture on the outside of one that looks like the imprint of a textile.

The high zinc content suggests an ocular purpose for this remarkably complex medicine. Pliny the Elder and Greek physician Pedanius Dioscorides both mention that zinc oxide was collected from the walls of furnaces used during copper casting and then used in medication for the eyes and skin. The large, round shape of the tablets — they’re 3-4 centimeters in diameter and half a centimeter thick — also indicate they were used for eye treatment. The Latin word for eyewash is collyrium, derived from the Greek word κoλλυρα which means “small round loaves,” a pretty dead-on accurate description of the shipwreck tablets.

As for how these pastilles would have been applied to the eye, that’s where the beeswax comes in. The pills were probably melted and the resulting unguent applied to the ailing eye.

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